Research

The Barnes lab uses behavioral, anatomical, electrophysiological, and molecular biological approaches in young and aged rodents, nonhuman primates and humans to investigate brain aging. 

The research conducted in this lab is centered on the following:

  • To examine the neurobiological mechanisms of normal memory decline with age in rodents, nonhuman primates and humans.
  • To understand how memory is impacted in the normal aging brain, so that abnormal departures from this can be detected and identified.
  • To transform what we learn in animal models of normal aging into treatments that optimize and extend the cognitive healthspan of older individuals.

 

 

Behavior

Instantaneous Cue Rotation Arena 

One of the behavioral apparatuses used for rodent spatial navigation tasks. 

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Electrophysiology

Electrophysiology in rodents

Electrophysiological recordings are used to investigate brain activity and electrical signals while animals perform tasks.

 

Crown SfN 2021 Poster

Crown SfN 2021 Poster

SfN 2021 Poster Presentation

view | download 1.88 MB

Molecular Biology

In situ Hybridization

Fluorescent in situ hybridization is used to tag and visualize mRNA expression in brain regions of interest. 

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Anatomy: MRI

Magnetic Resonance Imaging (MRI)

MR images are gathered and used to examine brain structures and study potential changes between young and aged animals.

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Anatomy: IHC

Immunohistochemistry

Using immunohistochemistry, fluorescent labeling, and microscopy we can visualize various neurobiological features in brain regions of interest. 

 

Khattab SfN 2021

Khattab SfN 2021

SfN 2021 Poster Presentation

view | download 683.87 KB

Anatomy: MRI Mapping

MRI Processing

MR images are mapped onto labeled brain atlases to get anatomical specificity. 

 

Do SfN 2021 Poster

Do SfN 2021 Poster

SfN 2021 Poster Presentation

view | download 6.07 MB